Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancer
نویسندگان
چکیده
منابع مشابه
Parkin and Parkinson disease.
Featured Article: Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, et al. Familial Parkinson disease gene product, parkin, is a ubiquitinprotein ligase. Nat Genet 2000;25:302–5. Since the 1970s, Japanese neurologists have described patients with autosomal recessive forms of familial Parkinson disease (PD), which have been termed “autosomal recessive juvenile parkinsonism” and “ea...
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BACKGROUND Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous cas...
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Essential tremor is one of the most frequent movement disorders of humans and can be associated with substantial disability. Some but not all persons with essential tremor develop signs of Parkinson disease, and the relationship between the conditions has not been clear. In a six-generation consanguineous Turkish kindred with both essential tremor and Parkinson disease, we carried out whole exo...
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Serine palmitoyltransferase (SPT) is a first-step enzyme in the sphingolipid biosynthetic pathway. Myriocin is an inhibitor of SPT and suppresses replication of the hepatitis C virus (HCV) replicon. However, it is still unknown whether this SPT inhibitor suppresses HCV replication in vivo. We investigated the anti-HCV effect of myriocin against intact HCV using chimeric mice with humanized live...
متن کامل3 Parkin and Parkinson ’ s Disease
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder affecting millions of predominantly elderly individuals worldwide. Originally described as “The Shaking Palsy” in 1817 by the British physician, James Parkinson, the disease is attended by a constellation of motoric deficits including bradykinesia (slowness in movements), postural instability, rigidity and tremor th...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci137411